Question:
Two strains of mice which are genetically identical except for a single genetic locus or region are said to be:
- Syngenic
- Allogenic
- Congenic
- Heterogenic
Rephrasing the question:
What is the term used for mice that are genetically identical except for one single locus?
Answer:
Congenic (option 3)
Explanation:
Let’s go through the options one by one.
- Syngenic: genetically identical, or sufficiently identical and immunologically compatible as to allow for transplantation. A syngeneic graft is also known as an isograft.
- Allogenic: genetically different because of being derived from separate individuals of the same species.
- Congenic: two strains/species that differ in only one locus and a linked segment of chromosome.
- Heterogenic: genetically different because of being derived from individuals of a different species
Sources:
https://en.wikipedia.org/wiki/Syngenic
https://en.wikipedia.org/wiki/Allotransplantation
https://en.wikipedia.org/wiki/Congenic
Rogner, U., Avner, P. Congenic mice: cutting tools for complex immune disorders. Nat Rev Immunol 3, 243–252 (2003).
http://www.informatics.jax.org/silver/frames/frame3-3.shtml
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